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KMID : 0361020110540120813
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Korean Journal of Otolaryngology - Head and Neck Surgery
2011 Volume.54 No. 12 p.813 ~ p.818
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p21-Activated Kinases (PAKs) as a Therapeutic Target
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Koo Bon-Seok
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Abstract
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p21-activated kinases (PAKs) are a family of serine/threonine protein kinases comprised of six isoform (PAK1-6), all of which are direct targets of the small GTPases Rac and Cdc42. PAKs have recently been shown to regulate various cellular activities, including cell motility, survival and proliferation, the organization and function of cytoskeleton and extracellular matrix, transcription and translation. PAKs are overexpressed or hyperactivated in several human tumor, such as breast cancer, gastric cancer, ovarian cancer etc., which makes them an attractive new therapeutic targets. Thus, there has been considerable interest in the development of inhibitors to the PAKs, as biological markers and leads for the development of therapeutics.
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KEYWORD
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p21-activated kinases, Neoplasms, Protein kinase inhibitors, Signal transduction
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